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371970 HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII

Primary Target: PKA
371970
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Tabulka spec. kláve

CAS #Empirical Formula
103745-39-7C₁₄H₁₇N₃O₂S · 2HCl

Products

Katalogové čísloBalení ks/bal.
371970-1MG Plastová ampulka 1 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 36 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Catalogue Number371970
Brand Family Calbiochem®
SynonymsFasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
References
ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
Swärd, K., et al. 2000. J. Physiol. 522, 33.
Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.
Product Information
CAS number103745-39-7
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPKA
Primary Target IC<sub>50</sub>10.7 µM inhibiting Rho-associated kinase (ROCK)
Primary Target K<sub>i</sub>.6 µM, 1.6 µM, 36 µM, inhibiting protein kinase A, protein kinase G, myosin light chain kinase, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Global Trade Item Number
Katalogové číslo GTIN
371970-1MG 04055977213539