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371964 HA 1004, Dihydrochloride

A cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A, CaM kinase II, myosin light chain kinase, protein kinase C.

HA 1004, Dihydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl

Primary Target: Protein kinase A
371964
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
92564-34-6C₁₂H₁₅N₅O₂S · 2HCl
Description
Overview

This product has been discontinued.





A cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A (Ki = 2.3 µM), CaM kinase II (Ki = 13 µM), myosin light chain kinase (Ki = 150 µM), protein kinase C (Ki = 40 µM), and protein kinase G (Ki = 1.3 µM). An intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
Catalogue Number371964
Brand Family Calbiochem®
SynonymsN-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl
References
ReferencesCrowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
Neveu, I., et al. 1992. Brain Res. 570, 316.
Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
Hidaka, H., et al. 1984. Biochemistry 23, 5036.
Product Information
CAS number92564-34-6
ATP CompetitiveY
FormWhite powder
Hill FormulaC₁₂H₁₅N₅O₂S · 2HCl
Chemical formulaC₁₂H₁₅N₅O₂S · 2HCl
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetProtein kinase A
Primary Target K<sub>i</sub>2.3 µM against protein kinase A
Purity>98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
371964 0

Documentation

HA 1004, Dihydrochloride MSDS

Title

Safety Data Sheet (SDS) 

HA 1004, Dihydrochloride Certificates of Analysis

TitleLot Number
371964

References

Přehled odkazů
Crowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
Neveu, I., et al. 1992. Brain Res. 570, 316.
Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
Hidaka, H., et al. 1984. Biochemistry 23, 5036.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-November-2009 RFH
SynonymsN-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl
DescriptionA cell-permeable, reversible, and ATP-competetive inhibitor of protein kinase A (Ki = 2.3 µM), CaM kinase II (Ki = 13 µM), myosin light chain kinase (Ki = 150 µM), protein kinase C (Ki = 40 µM), and protein kinase G (Ki = 1.3 µM). An intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
FormWhite powder
CAS number92564-34-6
Chemical formulaC₁₂H₁₅N₅O₂S · 2HCl
Structure formulaStructure formula
Purity>98% by TLC
SolubilityH₂O (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesCrowley, M.R., et al. 1994. J. Cardiovasc. Pharmacol. 23, 806.
Neveu, I., et al. 1992. Brain Res. 570, 316.
Leahy, J.C., and Vallano, M.L. 1991. Neuroscience 44, 361.
Kitazono, T., et al. 1989. Biochim. Biophys. Acta 1013, 152.
Asano, T., and Hidaka, H. 1984. J. Pharmacol. Exp. Ther. 231, 141.
Hidaka, H., et al. 1984. Biochemistry 23, 5036.

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Kategorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors