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368050 Granzyme B Inhibitor I - Calbiochem

The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Granzyme B Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-AAD-CMK

Primary Target: Granzyme B
368050
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₉H₂₄ClN₃O₇

Products

Katalogové čísloBalení ks/bal.
368050-1MG Plastová ampulka 1 mg
Description
OverviewA weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
Catalogue Number368050
Brand Family Calbiochem®
SynonymsZ-AAD-CMK
References
ReferencesGong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Product Information
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₉H₂₄ClN₃O₇
Chemical formulaC₁₉H₂₄ClN₃O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGranzyme B
Primary Target IC<sub>50</sub>300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Ala-Ala-Asp-CH₂Cl
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
368050-1MG 04055977192124

Documentation

Granzyme B Inhibitor I - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Granzyme B Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
368050

References

Přehled odkazů
Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry 30, 2217.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-July-2008 RFH
SynonymsZ-AAD-CMK
DescriptionA weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
FormOff-white solid
Chemical formulaC₁₉H₂₄ClN₃O₇
Peptide SequenceZ-Ala-Ala-Asp-CH₂Cl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry 30, 2217.