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368043 Granzyme B, Human, Recombinant, E. coli

Granzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GzmB

368043
  
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Description
OverviewRecombinant, human granzyme B expressed in E. coli. Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes (CTL) to induce target cell apoptosis. It is involved in the perforation of target cells and initiation of proteolysis that leads the cell into the apoptosis pathway.
Catalogue Number368043
Brand Family Calbiochem®
SynonymsGzmB
References
ReferencesWilharm, E., et al. 1999. J. Biol. Chem. 274, 27331.
Harris, J. L., et al. 1998. J. Biol. Chem. 273, 27364.
Product Information
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-<i>p</i>NA per min 25° C, pH 8.0.
EC number3.4.21.79
FormLiquid
FormulationIn TBS, 50% glycerol.
Applications
ApplicationGranzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.
Biological Information
Specific Activity≥7.0 units/µg protein
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Global Trade Item Number
Katalogové číslo GTIN
368043 0