400035 Sigma-AldrichGlucose Transporter Inhibitor II - Calbiochem

This product has been discontinued.

A cell-permeable thiazolidinedione compound that is shown to reversibly block glucose uptake in androgen-sensitive human prostate adenocarcinoma (LNCaP) cells transfected with GLUT1 (IC₅₀ = 2 µM). Blocks GLUT3, GLUT4, and GLUT9-mediated transport at higher concentration (IC₅₀ ≥ 5 µM). Binds to GLUT1 at a site that is distinct from the glucose binding site. Selectively reduces proliferation (IC₅₀ = 2.0 µM) and induces apoptosis (IC₅₀ = 2.5 µM) in LNCaP cells without affecting normal human prostate epithelial cells and mammary epithelial cells (~ 10 µM). Shown to elicit energy restriction-associated cellular responses in LNCaP cells, such as β-TrCP facilitated protein degradation, activation of AMP-activated kinase, and endoplasmic reticulum stress.