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371709 GPR109b Agonist - CAS 306935-41-1 - Calbiochem

The GPR109b Agonist, also referenced under CAS 306935-41-1, controls the biological activity of GPR109b. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid

371709
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
306935-41-1C₁₀H₁₁N₃O₂
Description
OverviewA cell-permeable Niacin (Cat. No. 481918) triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or β-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5 µM, Cat. No. 344270) and isoproterenol (1 µM, Cat. No. 420355), respectively, in GPR109b-expressing CHO cells (EC50 = 400 nM) and freshly isolated human adipocytes (EC50 about 1 µM).
Catalogue Number371709
Brand Family Calbiochem®
Synonyms1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid
References
ReferencesSemple, G., et al. 2006. J. Med. Chem. 49, 1227.
Product Information
CAS number306935-41-1
FormLight brown solid
Hill FormulaC₁₀H₁₁N₃O₂
Chemical formulaC₁₀H₁₁N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
371709 0

Documentation

GPR109b Agonist - CAS 306935-41-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

GPR109b Agonist - CAS 306935-41-1 - Calbiochem Certificates of Analysis

TitleLot Number
371709

References

Přehled odkazů
Semple, G., et al. 2006. J. Med. Chem. 49, 1227.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-March-2009 RFH
Synonyms1-(iso-Propyl)-1H-benzotriazole-5-carboxylic acid
DescriptionA cell-permeable Niacin (Cat. No. 481918) triazolo derivative that acts as a potent and selective agonist toward the human orphan G-protein-coupled receptor GPR109b/HM74, but not GPR109a/HM74A or β-adrenergic receptor. Effectively inhibits cAMP elevation induced by forskolin (5 µM, Cat. No. 344270) and isoproterenol (1 µM, Cat. No. 420355), respectively, in GPR109b-expressing CHO cells (EC50 = 400 nM) and freshly isolated human adipocytes (EC50 about 1 µM).
FormLight brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number306935-41-1
Chemical formulaC₁₀H₁₁N₃O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesSemple, G., et al. 2006. J. Med. Chem. 49, 1227.