341220 Sigma-AldrichExo1 - CAS 75541-83-2 - Calbiochem
A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells by inducing tubulation and collapsing of the Golgi membrane.
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Synonyms: 2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
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Přehled
Tabulka spec. kláve
| CAS # | Empirical Formula |
|---|---|
| 75541-83-2 | C₁₅H₁₂FNO₃ |
Products
| Katalogové číslo | Balení | ks/bal. | |
|---|---|---|---|
| 341220-25MG | Plastová ampulka | 25 mg |
| Description | |
|---|---|
| Overview | A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies. |
| Catalogue Number | 341220 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I |
| References | |
|---|---|
| References | Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469. |
| Product Information | |
|---|---|
| CAS number | 75541-83-2 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₅H₁₂FNO₃ |
| Chemical formula | C₁₅H₁₂FNO₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Golgi ARF1 GTPase |
| Primary Target IC<sub>50</sub> | 20 µM inhibiting vesicular traffic from ER to Golgi in BSC1 cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Katalogové číslo | GTIN |
| 341220-25MG | 04055977215496 |