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05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action
05-23-3800
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅

Products

Katalogové čísloBalení ks/bal.
05-23-3800-0.1MG Plastová ampulka .1 mg
05-23-3800-0.5MG Plastová ampulka .5 mg
05-23-3800-1MG Plastová ampulka 1 mg
Description
OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
Catalogue Number05-23-3800
Brand Family Calbiochem®
SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
References
ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
Yanagisawa, M., et al. 1988. Nature 332, 411.
Product Information
CAS number117399-94-7
ATP CompetitiveN
FormWhite to off-white solid
FormulationSupplied as an acetate salt.
Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPotent vasoconstrictive action
Purity≥96% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
05-23-3800-0.1MG 04055977226775
05-23-3800-0.5MG 04055977226782
05-23-3800-1MG 04055977226799

Documentation

Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem Certificates of Analysis

TitleLot Number
05-23-3800

References

Přehled odkazů
Cesari, M., et al. 1996. Am. Heart J. 132, 1236.
Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
Yanagisawa, M., et al. 1988. Nature 332, 411.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-May-2008 JSW
SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
DescriptionA 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
FormWhite to off-white solid
FormulationSupplied as an acetate salt.
CAS number117399-94-7
Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Purity≥96% by HPLC
Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity Standard Handling
ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
Yanagisawa, M., et al. 1988. Nature 332, 411.