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324768 Endostatin, Human, Recombinant, Pichia pastoris

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324768
  
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Description
OverviewRecombinant, human endostatin expressed in Pichia pastoris. Endostatin is a ~20 kDa C-terminal fragment of collagen XVIII that acts as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to apoptosis in endothelial cells.
Catalogue Number324768
Brand Family Calbiochem®
References
ReferencesDixelius, J., et al. 2000. Blood 95, 3403. Boehm, T., et al. 1999. Yeast 15, 563. Dhanabal, M., et al. 1999. Biochem. Biophys. Res. Commun. 258, 345. Dhanabal, M., et al. 1999. J. Biol. Chem. 274, 11721. Moulton, K.S., et al. 1999. Circulation 99, 1726. OʹReilly, M.S., et al. 1997. Cell 88, 277.
Product Information
DeclarationSold under license of U.S. Patents 6,764,995, 6,746,865 and corresponding patents.
FormLiquid
FormulationIn 66 mM sodium phosphate, 59 mM NaCl, 17 mM citric acid, pH 6.2.
Biological Information
Biological activity10 µg/ml endostatin will inhibit 50% tube formation in the presence of 10 ng/ml VEGF and 70% tube formation in the presence of 5 ng/ml bFGF
Purity≥95% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
ContaminantsEndotoxin: ≤ 0.50 EU/mg protein
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Global Trade Item Number
Katalogové číslo GTIN
324768 0