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328007 ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine

Primary Target: ERK1 and ERK2
328007
  
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Tabulka spec. kláve

CAS #Empirical Formula
865362-74-9C₁₈H₁₃N₇
Description
Overview

This product has been discontinued.



A cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 = 3.1 µM). ERK Inhibitor II, Negative Control is also available (Cat. No. 328008). Also available as a 10 mM solution in DMSO (Cat. No. 328010).
Catalogue Number328007
Brand Family Calbiochem®
Synonyms5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
References
ReferencesOhori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.
Product Information
CAS number865362-74-9
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₈H₁₃N₇
Chemical formulaC₁₈H₁₃N₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetERK1 and ERK2
Primary Target IC<sub>50</sub>510 nM and 330 nM
Primary Target K<sub>i</sub>310 nM and 140 nM, against ERK1 and ERK2, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
328007 0