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324510 EF24 - Calbiochem

EF24 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV

324510
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₉H₁₅F₂NO
Description
Overview

This product has been discontinued.



A cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 µM) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 µM) and NF-κB nuclear translocation (IC50 = 1.3 µM), as well as in its anticancer activity (IC50 ranges from 0.44 to 2.07 µM) in vitro. Reported to completely stop the expansion of HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.
Catalogue Number324510
Brand Family Calbiochem®
Synonyms3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV
References
ReferencesSubramaniam, D., et al. 2008. Cancer Res. 68, 1962.
Product Information
FormYellow solid
Hill FormulaC₁₉H₁₅F₂NO
Chemical formulaC₁₉H₁₅F₂NO
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. When stored at room temperature in DMSO, 2.5% decomposition per day is expected.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
324510 0

Documentation

EF24 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

EF24 - Calbiochem Certificates of Analysis

TitleLot Number
324510

References

Přehled odkazů
Subramaniam, D., et al. 2008. Cancer Res. 68, 1962.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-April-2012 JSW
Synonyms3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV
DescriptionA cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 vs. 20 µM, respectively) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 vs. >50 µM, respectively) and NF-κB nuclear translocation (IC50 = 1.3 vs. 13 µM, respectively) in A549 cultures, as well as in its anticancer activity (EC50 ranges from 0.44 to 2.07 µM against various cancer cell lines). Reported to completely stop the continued volume expansion of 1-week-old HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉H₁₅F₂NO
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (15 mg/ml) or Ethanol (4 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. When stored at room temperature in DMSO, 2.5% decomposition per day is expected.
Toxicity Regulatory Review
ReferencesSubramaniam, D., et al. 2008. Cancer Res. 68, 1962.