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532089 Dual DYRK/CLK inhibitor, Cpd 23 - Calbiochem

Dual DYRK/CLK inhibitor, Cpd 23 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pre-mRNA Splicing Modulator, DYRK Inhibitor, Cdc2-like Kinase Inhibitor

Primary Target: DYRK/CLK
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Tabulka spec. kláve

Empirical Formula
C₁₀H₈O₂S
Description
Overview

This product has been discontinued.



A cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC50 = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC50 = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC50 = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC50 = 8.9 µM) in cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number532089
Brand Family Calbiochem®
SynonymsPre-mRNA Splicing Modulator, DYRK Inhibitor, Cdc2-like Kinase Inhibitor
References
ReferencesSchmitt, C., et al. 2014. ACS Med. Chem. Lett. 5, 963.
Product Information
FormYellow powder
Hill FormulaC₁₀H₈O₂S
Chemical formulaC₁₀H₈O₂S
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetDYRK/CLK
Primary Target IC<sub>50</sub>60 nM, EC₅₀
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
532089 0