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324377 Donepezil Hydrochloride - Calbiochem

A brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC₅₀ = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase.

Donepezil Hydrochloride - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: E2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride

324377
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₄H₂₉NO₃HCl
Description
Overview

This product has been discontinued.



A brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC50 = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase. In vivo, there is a marked and significant increase in acetylcholine content in rat cerebral cortex at a p.o. dose of 5 mg/kg. Furthermore, it inhibits brain cholinesterase (ChE) dose-dependently (ID50 = 2.6 mg/kg) without any marked adverse effects on ChE in the heart and small intestine. In a clinical trial, it has been shown to reduce AChE activity by 63.7% for the 5mg/d group and 77.3% for the 10mg/d group in Alzheimer's disease patients. Its off-target effects are indicated with the reversibly of inhibited voltage-gated K+/Na+ channels.
Catalogue Number324377
Brand Family Calbiochem®
SynonymsE2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride
References
ReferencesYu, B., et al. 2005. Eur J Pharm 508, 15.
Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
Rogers, S., et al. 1998. Neurology 50, 136.
Product Information
FormWhite solid
Hill FormulaC₂₄H₂₉NO₃HCl
Chemical formulaC₂₄H₂₉NO₃HCl
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
324377 0

Documentation

Donepezil Hydrochloride - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Donepezil Hydrochloride - Calbiochem Certificates of Analysis

TitleLot Number
324377

References

Přehled odkazů
Yu, B., et al. 2005. Eur J Pharm 508, 15.
Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
Rogers, S., et al. 1998. Neurology 50, 136.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-November-2011 RFH
SynonymsE2020, (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]-methylpiperidine hydrochloride
DescriptionA brain-penetrating, reversible, and selective piperidine acetylcholinesterase inhibitor with an IC50 = 5.7 nM in vitro, and a 1250-fold selectivity over butylcholinesterase. In vivo, there is a marked and significant increase in acetylcholine content in rat cerebral cortex at a p.o. dose of 5 mg/kg. Furthermore, it inhibits brain cholinesterase (ChE) dose-dependently (ID50 = 2.6 mg/kg) without any marked adverse effects on ChE in the heart and small intestine. In a clinical trial, it has been shown to reduce AChE activity by 63.7% for the 5mg/d group and 77.3% for the 10mg/d group in Alzheimer's disease patients. Its off-target effects are indicated with the reversibly of inhibited voltage-gated K+/Na+ channels.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₂₉NO₃HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (16 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYu, B., et al. 2005. Eur J Pharm 508, 15.
Ogura, H., et al. 2000. Nippon Yakurigaky Zasshi 115, 45.
Sugimoto, H., et al. 1995. J Med Chem 38, 4821.
Rogers, S., et al. 1998. Neurology 50, 136.