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323115 DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123

323115
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
101860-83-7C₉H₈BrNO₃
Description
Overview

This product has been discontinued.



A cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
Catalogue Number323115
Brand Family Calbiochem®
Synonyms4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
References
ReferencesLally, B.E., et al. 2007. Cancer Res. 67, 8791.
Product Information
CAS number101860-83-7
FormOff-white solid
Hill FormulaC₉H₈BrNO₃
Chemical formulaC₉H₈BrNO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
323115 0

Documentation

DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem Certificates of Analysis

TitleLot Number
323115

References

Přehled odkazů
Lally, B.E., et al. 2007. Cancer Res. 67, 8791.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-August-2011 JSW
Synonyms4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123
DescriptionA cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number101860-83-7
Chemical formulaC₉H₈BrNO₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLally, B.E., et al. 2007. Cancer Res. 67, 8791.