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218729 Caspase Inhibitor VIII

The Caspase Inhibitor VIII controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

Caspase Inhibitor VIII MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-VDVAD-CHO

Primary Target: caspase-2
218729
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₃H₃₇N₅O₁₀
Description
Overview

This product has been discontinued.





A potent, reversible inhibitor of caspase-2 (Ki = 3.5 nM), caspase-3 (Ki = 1 nM) and caspase-7 (Ki = 7.5 nM). Also serves as an inhibitor of DRONC (Drosophila caspase), a glutamate/aspartate protease.
Catalogue Number218729
Brand Family Calbiochem®
SynonymsAc-VDVAD-CHO
References
ReferencesDorstyn, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4307.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Product Information
ATP CompetitiveN
FormOff-white lyophilized solid
Hill FormulaC₂₃H₃₇N₅O₁₀
Chemical formulaC₂₃H₃₇N₅O₁₀
ReversibleY
Applications
Biological Information
Primary Targetcaspase-2
Primary Target K<sub>i</sub>3.5 nM, 1 nM, 7.5 nM, against caspase-2, caspase-3. and caspase-7, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Val-Asp-Val-Ala-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
218729 0

Documentation

Caspase Inhibitor VIII Certificates of Analysis

TitleLot Number
218729

References

Přehled odkazů
Dorstyn, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4307.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Název
  • Zhonghua Gao, Yufang Shao and Xuejun Jiang. (2005) Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. Journal of Biological Chemistry 280, 38271-38275.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision04-June-2008 RFH
    SynonymsAc-VDVAD-CHO
    DescriptionA potent, reversible inhibitor of caspase-2 (Ki = 3.5 nM), caspase-3 (Ki = 1.0 nM), and caspase-7 (Ki = 7.5 nM). Also serves as an inhibitor of DRONC (Drosophilia caspase), an ecdysone-inducible glutamate/aspartate caspase. Recommended for use with cells extracts and purified caspases.
    FormOff-white lyophilized solid
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₂₃H₃₇N₅O₁₀
    Peptide SequenceAc-Val-Asp-Val-Ala-Asp-CHO
    Purity≥95% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesDorstyn, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4307.
    Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
    Citation
  • Zhonghua Gao, Yufang Shao and Xuejun Jiang. (2005) Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. Journal of Biological Chemistry 280, 38271-38275.
    		•