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208901 Calpastatin, Human Erythrocytes

Calpastatin, Human Erythrocytes MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
208901
  
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Přehled

Replacement Information
Description
OverviewTetrameric protein that is a specific, endogenous inhibitor of the calcium-activated neutral proteinases. It is upregulated in response to hypoxia and may have a protective role in minimizing hypoxic damage.
Catalogue Number208901
Brand Family Calbiochem®
References
ReferencesBlomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. Shigeta, K., et al. 1994. Biochem. Int. 9, 327. Parkes, C. 1986. in Proteinase Inhibitors (Barrett and Salvesen, Eds.) Vol. 19, p. 571, Elsevier Science Publishers BV (Biomedical Division). Melloni, E., et al. 1982. Biochem. Biophys. Res. Commun. 106, 731.
Product Information
Unit of DefinitionOne unit is defined as the amount of protein that will inhibit the increase in absorbance at 750 nm by 1.0 induced by one unit of Calpain-1 (<a href ="/Products/ProductDisplay.asp→catNO=208712">Cat. No. 208712</a>) at 30°C, pH 7.5 using casein as a substrate.
FormLiquid
FormulationIn 30 mM Tris-HCl, 1 mM EDTA, 1 mM EGTA, 600 µM DTT, 40% glycerol, pH 7.4.
Applications
Biological Information
Primary Targetcalcium activated neutral proteinases
SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥1000 units/mg protein
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
208901 0

Documentation

Calpastatin, Human Erythrocytes Certificates of Analysis

TitleLot Number
208901

References

Přehled odkazů
Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. Shigeta, K., et al. 1994. Biochem. Int. 9, 327. Parkes, C. 1986. in Proteinase Inhibitors (Barrett and Salvesen, Eds.) Vol. 19, p. 571, Elsevier Science Publishers BV (Biomedical Division). Melloni, E., et al. 1982. Biochem. Biophys. Res. Commun. 106, 731.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-December-2008 RFH
DescriptionTetrameric protein that is a specific, endogenous inhibitor of the calcium-activated neutral proteinases.
FormLiquid
FormulationIn 30 mM Tris-HCl, 1 mM EDTA, 1 mM EGTA, 600 µM DTT, 40% glycerol, pH 7.4.
SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific activity≥1000 units/mg protein
Unit definitionOne unit is defined as the amount of protein that will inhibit the increase in absorbance at 750 nm by 1.0 induced by one unit of Calpain-1 (Cat. No. 208712) at 30°C, pH 7.5 using casein as a substrate.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesBlomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. Shigeta, K., et al. 1994. Biochem. Int. 9, 327. Parkes, C. 1986. in Proteinase Inhibitors (Barrett and Salvesen, Eds.) Vol. 19, p. 571, Elsevier Science Publishers BV (Biomedical Division). Melloni, E., et al. 1982. Biochem. Biophys. Res. Commun. 106, 731.