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207001 Calcineurin Autoinhibitory Peptide, Cell-permeable - Calbiochem

The Calcineurin Autoinhibitory Peptide, Cell-permeable controls the biological activity of Mn2+-stimulated calcineurin activity. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂

Primary Target: Blocks CaN-dependent NFAT nuclear translocation
207001
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₃₇H₂₅₁N₇₁O₃₄S₂

Products

Katalogové čísloBalení ks/bal.
207001-1MG Plastová ampulka 1 mg
Description
OverviewA cell-permeable peptide that is composed of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction domain (11R) and acts as an inhibitor of CaN phosphatase activity. Blocks CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Protects neuronal cells from glutamate-induced cell death.
Catalogue Number207001
Brand Family Calbiochem®
Synonyms11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂
References
ReferencesTerada, H., et al. 2003. J. Neurochem. 87, 1145.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₃₇H₂₅₁N₇₁O₃₄S₂
Chemical formulaC₁₃₇H₂₅₁N₇₁O₃₄S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetBlocks CaN-dependent NFAT nuclear translocation
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
207001-1MG 04055977203196

Documentation

Calcineurin Autoinhibitory Peptide, Cell-permeable - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Calcineurin Autoinhibitory Peptide, Cell-permeable - Calbiochem Certificates of Analysis

TitleLot Number
207001

References

Přehled odkazů
Terada, H., et al. 2003. J. Neurochem. 87, 1145.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2008 RFH
Synonyms11R-CaN-AID, Ac-RRRRRRRRRRRGGGRMAPPRRDAMPSDA-NH₂
DescriptionA cell-permeable peptide that consists of the calcineurin (CaN) autoinhibitory domain (AID) fused to a poly-arginine-based protein transduction doamin (11R) and acts as an inhibitor of CaN phosphatase activity. Reported to block CaN-dependent NFAT nuclear translocation and NFAT promoter activity in neurons. Also reported to protect neuronal cells from glutamate-induced cell death.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃₇H₂₅₁N₇₁O₃₄S₂
Peptide SequenceAc-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Arg-Met-Ala-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-Ser-Asp-Ala-NH₂
Purity≥98% by HPLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesTerada, H., et al. 2003. J. Neurochem. 87, 1145.