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534363 CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem

A 11-mer peptide that mimics CTNF action and rescues autism sera-induced cell death and oxidative stress in cultured cortical neurons. Exerts its neuroprotective effect by enhancing BDNF expression.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ciliary Neurotrophic Factor Epitope Peptide 6

534363
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
1312886-56-8C₅₅H₉₀N₁₄O₁₆

Products

Katalogové čísloBalení ks/bal.
5.34363.0001 Skleněná láhev 10 mg
Description
OverviewA brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number534363
Brand Family Calbiochem®
SynonymsCiliary Neurotrophic Factor Epitope Peptide 6
DescriptionCNTF Mimetic, P6 Peptide
References
ReferencesKazim, S., et al. 2015. Plos One. 10, e0118627.
Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
Li, B., et al. 2010. FEBS Lett. 584,3359.
Product Information
CAS number1312886-56-8
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₅₅H₉₀N₁₄O₁₆
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-VGDGGLFEKKL-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
5.34363.0001 04054839117169

Documentation

CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

CNTF Mimetic, P6 Peptide - CAS 1312886-56-8 - Calbiochem Certificates of Analysis

TitleLot Number
534363

References

Přehled odkazů
Kazim, S., et al. 2015. Plos One. 10, e0118627.
Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
Li, B., et al. 2010. FEBS Lett. 584,3359.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-November-2016 JSW
SynonymsCiliary Neurotrophic Factor Epitope Peptide 6
DescriptionA brain-penetrating 11-mer peptide derived from the active region of human ciliary neurotrophic factor (CTNF; aa 146-156) that rescues autism sera-induced cell death and oxidative stress in mouse cultured cortical neurons in a dose-dependent manner (5 nM to 1 µM). Also shown to abrogate behavioral autistic phenotype in autism sera induced rat model. Exerts its neuroprotective effect by modulating CNTF/JAK/STAT pathway and LIF signaling and by enhancing the expression of brain derived neurotrophic factor (BDNF). Enhances hippocampus-dependent learning and memory, increased neurogenesis and neuronal plasticity in normal adult mice. Exhibits desirable plasma half-life (6 hours) and is devoid of any adverse effects normally associated with the full-length protein. Potentiates neurogenesis in the AβPP Tg mice by augmenting cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number1312886-56-8
Peptide SequenceAc-VGDGGLFEKKL-NH₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml) or H₂O (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKazim, S., et al. 2015. Plos One. 10, e0118627.
Rockenstein, E., et al. 2011. J. Alzheimers Dis. 27, 743,
Li, B., et al. 2010. FEBS Lett. 584,3359.