506384 Sigma-AldrichBLM Helicase Inhibitor, ML216 - CAS 1430213-30-1 - Calbiochem
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Tabulka spec. kláve
| CAS # | Empirical Formula |
|---|---|
| 1430213-30-1 | C₁₅H₉F₄N₅OS |
Products
| Katalogové číslo | Balení | ks/bal. | |
|---|---|---|---|
| 5.06384.0001 | Skleněná láhev | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable pyridinyl-thiadiazolylurea compound that selectively blocks Bloom′s syndrome protein (BLM) helicase activity of both full-length as well as truncated BLM636-1298 forms (IC50 = 2.98 and 0.97 µM, respectively). Competes with and reversibly blocks DNA binding to BLM. However, the inhibition appears to be non-competitive with respect to ATP. Exhibits anti-proliferative activity in cells expressing BLM, but not in those lacking BLM. Induces sister chromatid exchanges (SCEs) and enhances the sensitivity of BLM containing PSNF5 cells to aphidicolin (Cat. No. 178273) without affecting PSNG13 cells that are devoid of BLM. Displays favorable microsomal (T1/2 > 1.2 h) and plasma stability (~100% at 5 h). |
| Catalogue Number | 506384 |
| Brand Family | Calbiochem® |
| Synonyms | 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea, ML-216 |
| References | |
|---|---|
| References | Rosenthal, A.S., et al. 2013. Bioorg. Med. Chem. Lett. 23, 5660. Nguyen, G.H., et al. 2013. Chem. Biol. 20, 55. |
| Product Information | |
|---|---|
| CAS number | 1430213-30-1 |
| Form | Orange solid |
| Hill Formula | C₁₅H₉F₄N₅OS |
| Chemical formula | C₁₅H₉F₄N₅OS |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | BLM |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Katalogové číslo | GTIN |
| 5.06384.0001 | 04055977243284 |