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MABT107 Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1

This Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1 is validated for use in western blotting for the detection of Src-like-adapter/SLAP1.

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Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: SLA, SLAP, SLAP1 UniProt Number: Q13239
MABT107
100 µL  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABT107
DescriptionAnti-Src-like-adapter Antibody/SLAP1, clone 1D9.1
Alternate Names
  • Src-like-adapter
  • Src-like-adapter protein 1
  • SLAP-1
  • hSLAP
Background InformationSrc-like-adapter/SLAP1 protein, also known as SLAP, and encoded by the gene SLA/SLAP/SLAP1, is an adapter protein which negatively regulates T cell receptor signaling by inhibiting T cell antigen induced proliferation and works to control the positive selection and mitosis of T cells. SLAP1 also acts to connect signaling proteins such as ZAP70 with the T cell specific CBL ubiquitin ligase that plays a central role in degrading signaling proteins, and a critical role in limiting or initiating the T-cell specific- antigen-specific immunotolerance limits in T cells activation. Src-like-adapter/SLAP1 is localized to the cytoplasm and endosomes within cells. Src-like-adapter/SLAP1 is expressed in lung and fetal brain, and weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. Recent research suggest that SLAP1 may also play a role in different cancers and in modulation of receptor tyrosine kinase signaling in cancers apart from its conventional role in regulation of T cell receptor stability.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1 is validated for use in western blotting for the detection of Src-like-adapter/SLAP1.
Key Applications
  • Western Blotting
Biological Information
ImmunogenLinear peptide corresponding to human Src-like-adapter/SLAP1.
Clone1D9.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgMκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SLA
  • SLAP
  • SLAP1
UniProt Number
Molecular Weight~38 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it may be observed at higher molecular weights due to known Post-translational modification sites.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Human Lung tissue lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected Src-like-adapter/SLAP1 in 400 µg of human lung tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABT107 04053252966125