Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

PC152 Anti-Pan β-Amyloid (1-40) Rabbit pAb

Anti-Pan β-Amyloid (1-40) Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
PC152
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes all three β-amyloid peptides, Aβ40, Aβ42, and Aβ43.
  • Antibody Target Gene Symbol: APP
  • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
  • Entrez Gene Name: amyloid beta (A4) precursor protein
  • Hu Entrez ID: 351 (Related Antibodies: 171610, PC729,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
  • Mu Entrez ID: 11820
  • Rat Entrez ID: 54226
    		•
    Catalogue NumberPC152
    Brand Family Calbiochem®
    References
    ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
    Borchelt, D.R., et al. 1997. Neuron 19, 939.
    Citron, M., et al. 1997. Nature Med. 3, 67.
    Hardy, J. 1997. Trends in Neurosci. 20, 154.
    Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
    Duff, K., et al. 1996. Nature 383, 710.
    Iwatsubo, T., et al. 1994. Neuron 13, 45.
    Suzuki, N., et al. 1994. Science 264, 133.
    Product Information
    FormLiquid
    FormulationIn PBS.
    PreservativeNone
    Applications
    Key Applications Dot Blot
    Enzyme-Linked Immunosorbent Assay
    Immunohistochemistry
    Radioimmunoassay
    Application NotesDot Blot (see comments)
    ELISA (1 µg/ml)
    Immunohistochemistry (see comments)
    Radioimmunoassay (see comments)
    Application CommentsThis antibody is not blocked by β-amyloid peptide [1-12] whereas, β-amyloid peptide [14-35], β-amyloid peptide [15-28], β-amyloid peptide [17-30] and β-amyloid peptide [1-40] were all able to block antibody activity. This antibody is also reported to work for dot blots, immunohistochemistry, and radioimmunoassay. Antibody should be titrated for optimal results in individual systems.
    Biological Information
    Immunogena synthetic peptide corresponding to amino acids 1-40 of human Aβ₁₋₄₀ peptide
    ImmunogenHuman
    HostRabbit
    IsotypeIgG
    Concentration Label Please refer to vial label for lot-specific concentration
    Physicochemical Information
    Dimensions
    Materials Information
    Toxicological Information
    Safety Information according to GHS
    Safety Information
    Product Usage Statements
    Storage and Shipping Information
    Ship Code Dry Ice Only
    Toxicity Standard Handling
    Storage -20°C
    Avoid freeze/thaw Avoid freeze/thaw
    Do not freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C)
    Packaging Information
    Transport Information
    Supplemental Information
    Specifications
    Global Trade Item Number
    Katalogové číslo GTIN
    PC152 0

    Documentation

    Anti-Pan β-Amyloid (1-40) Rabbit pAb MSDS

    Title

    Safety Data Sheet (SDS) 

    Anti-Pan β-Amyloid (1-40) Rabbit pAb Certificates of Analysis

    TitleLot Number
    PC152

    References

    Přehled odkazů
    Savage, M.J., et al. 1998. J. Neurosci. 15, 1743.
    Borchelt, D.R., et al. 1997. Neuron 19, 939.
    Citron, M., et al. 1997. Nature Med. 3, 67.
    Hardy, J. 1997. Trends in Neurosci. 20, 154.
    Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
    Duff, K., et al. 1996. Nature 383, 710.
    Iwatsubo, T., et al. 1994. Neuron 13, 45.
    Suzuki, N., et al. 1994. Science 264, 133.
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-February-2012 JSW
    ApplicationDot Blot (see comments)
    ELISA (1 µg/ml)
    Immunohistochemistry (see comments)
    Radioimmunoassay (see comments)
    DescriptionProtein G purified rabbit polyclonal antibody. Recognizes Aβ1-40, Aβ1-42, and Aβ1-43.
    BackgroundA number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer's Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing of βAPP, resulting in increased extracellular concentration of β-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of Aβ leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recognizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin and βAPP mutants while other studies have used Aβ specific antibodies to prevent the in vitro fibrillar aggregation of Aβ.
    HostRabbit
    Immunogen speciesHuman
    Immunogena synthetic peptide corresponding to amino acids 1-40 of human Aβ₁₋₄₀ peptide
    IsotypeIgG
    Specieshuman
    FormLiquid
    FormulationIn PBS.
    Concentration Label Please refer to vial label for lot-specific concentration
    PreservativeNone
    CommentsThis antibody is not blocked by β-amyloid peptide [1-12] whereas, β-amyloid peptide [14-35], β-amyloid peptide [15-28], β-amyloid peptide [17-30] and β-amyloid peptide [1-40] were all able to block antibody activity. This antibody is also reported to work for dot blots, immunohistochemistry, and radioimmunoassay. Antibody should be titrated for optimal results in individual systems.
    Storage Avoid freeze/thaw
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C)
    Toxicity Standard Handling
    ReferencesSavage, M.J., et al. 1998. J. Neurosci. 15, 1743.
    Borchelt, D.R., et al. 1997. Neuron 19, 939.
    Citron, M., et al. 1997. Nature Med. 3, 67.
    Hardy, J. 1997. Trends in Neurosci. 20, 154.
    Solomon, B., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 4109.
    Duff, K., et al. 1996. Nature 383, 710.
    Iwatsubo, T., et al. 1994. Neuron 13, 45.
    Suzuki, N., et al. 1994. Science 264, 133.