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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MAB3731 Sigma-AldrichAnti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
User Guides

Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: MET, AUTS9, c-Met, RCCP2, HGFR, EC 2.7.10.1 UniProt Number: P08581

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Tabulka spec. kláve

Species Reactivity	Key Applications	Host	Format	Antibody Type
H, M	ELISA	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MAB3731
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877
Alternate Names	c-Met cmet HGFR RCCP2 met proto-oncogene (hepatocyte growth factor receptor)

References

Product Information
Format	Purified
HS Code	3002 15 90
Presentation	Protein G purified immunoglobulin. Liquid in PBS containing 0.09% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 detects level of Met/HGFR & has been published & validated for use in ELISA.
Key Applications	ELISA
Application Notes	ELISA (direct): 1:1,000 Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Synthetic phospho-peptide corresponding to residues surrounding Tyr1234/1235 of human Met.
Epitope	phospho-specific (Tyr1234/1235)
Clone	6AT1877
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Specificity	Reacts with Met/HGFR (Hepatocyte growth factor receptor) only when phosphorylated at Tyr1234 and Tyr1235. The Met receptor tyrosine kinase is the prototypical member of a small subfamily of growth factor receptors that when activated, induces mitogenic, motogenic, and morphogenic cellular responses. The ligand for Met is hepatocyte growth factor/scatter factor (HGF/SF) and while normal HGF/SF-Met signaling is required for embryonic development, abnormal Met signaling has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes.
Isotype	IgG1
Species Reactivity	Human Mouse
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NM_000245.2
Entrez Gene Summary	The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
Gene Symbol	MET AUTS9 c-Met RCCP2 HGFR EC 2.7.10.1
Modifications	Phosphorylation
UniProt Number	P08581
UniProt Summary	FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. SIZE: 1390 amino acids; 155527 Da SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

Storage and Shipping Information

Storage Conditions

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Katalogové číslo	GTIN
MAB3731	04053252617270

Documentation

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 MSDS

Title
Safety Data Sheet (SDS)

Anti-Met/HGFR Antibody, phospho-specific (Tyr1234/1235), clone 6AT1877 Certificates of Analysis

Title	Lot Number
MOUSE ANTI-PHOSPHO-MET/HGFR (TYR1234/1235) MONOCLONAL ANTIBODY - 2395639	2395639
MOUSE ANTI-PHOSPHO-MET/HGFR (TYR1234/1235) - 3732971	3732971

References

Reference overview	Pub Med ID
EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells. Gaëtan J-R Delcroix,Kevin M Curtis,Paul C Schiller,Claudia N Montero-Menei Differentiation; research in biological diversity 80 2001 Zobrazit abstrakt Multipotent mesenchymal stromal cells raise great interest for regenerative medicine studies. Some MSC subpopulations have the potential to undergo neural differentiation, including marrow isolated adult multilineage inducible (MIAMI) cells, which differentiate into neuron-like cells in a multi-step neurotrophin 3-dependent manner. Epidermal and basic fibroblast growth factors are often used in neuronal differentiation protocols for MSCs, but with a limited understanding of their role. In this study, we thoroughly assessed for the first time the capacity of these factors to enhance the neuronal differentiation of MSCs.	20813449

Reference overview

Pub Med ID

User Guides

Title
MOUSE ANTI-PHOSPHO-MET/HGFR (TYR1234/1235) MONOCLONAL ANTIBODY

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Kategorie

Life Science Research > Antibodies and Assays > Primary Antibodies

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