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CBL1348 Anti-Integrin beta1 Antibody, clone HM beta 1.1

Detect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: CD29, FNRB, GPIIA , MDF2 , MSK12 , OTTHUMP00000019420 , OTTHUMP00000046253, OTTHUMP00000063731, OTTHUMP00000063732, OTTHUMP00000063733, VLA-BETA, VLAB UniProt Number: P09055
CBL1348
100 µg  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MICCHtPurifiedMonoclonal Antibody
Description
Catalogue NumberCBL1348
DescriptionAnti-Integrin beta1 Antibody, clone HM beta 1.1
Alternate Names
  • CD29 antigen
  • Fibronectin receptor subunit beta
  • Integrin VLA-4 subunit beta
  • fibronectin receptor beta subunit
  • integrin VLA-4 beta subunit
  • integrin beta 1
  • integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen
    CD29 includes MDF2, MSK12)
Background InformationIntegrin beta 1is also known as CD29. It is a transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits, forming the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions such as hemostasis, embryonic development, wound repair, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion.
References
Product Information
FormatPurified
HS Code3002 15 90
Control
  • NIH3T3, A431
PresentationPurified in PBS with 0.05% NaN3.
Quality LevelMQ100
Applications
ApplicationDetect Integrin beta1 using this Anti-Integrin beta1 Antibody, clone HM beta 1.1 validated for use in IC.
Key Applications
  • Immunocytochemistry
Biological Information
ImmunogenPurified mouse VLA-4 antigen
EpitopeFull length
CloneHM beta 1.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostHamster
IsotypeIgG
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteReacts with mouse and human. Other species have not been tested.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryIntegrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq]
Gene Symbol
  • CD29
  • FNRB
  • GPIIA
  • MDF2
  • MSK12
  • OTTHUMP00000019420
  • OTTHUMP00000046253
  • OTTHUMP00000063731
  • OTTHUMP00000063732
  • OTTHUMP00000063733
  • VLA-BETA
  • VLAB
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA, FLNB, FLNC and RANBP9. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity).
LOCATION: Membrane; Single-pass type I membrane protein. Melanosome (By similarity).
SIMILARITY: Belongs to the integrin beta chain family.
SIMILARITY: Contains 1 VWFA domain.
Molecular Weight130 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunocytochemistry on mouse NIH3T3, A431 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
CBL1348 04053252516559

Documentation

Anti-Integrin beta1 Antibody, clone HM beta 1.1 MSDS

Title

Safety Data Sheet (SDS) 

Anti-Integrin beta1 Antibody, clone HM beta 1.1 Certificates of Analysis

TitleLot Number
Anti-Integrin beta1, clone HM beta 1.1 - 2424779 2424779
Anti-Integrin beta1, clone HM beta 1.1 - 2011462 2011462
Anti-Integrin beta1, clone HM beta 1.1 - 2109564 2109564
Anti-Integrin beta1, clone HM beta 1.1 - 2300032 2300032
Anti-Integrin beta1, clone HM beta 1.1 - 3176037 3176037
Anti-Integrin beta1, clone HM beta 1.1 - 3259522 3259522
Anti-Integrin beta1, clone HM beta 1.1 - 3380295 3380295
Anti-Integrin beta1, clone HM beta 1.1 - LV1758406 LV1758406
Anti-Integrin beta1, clone HM beta 1.1 - NG1554550 NG1554550
Anti-Integrin beta1, clone HM beta 1.1 - NG1873185 NG1873185
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