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MABS1140 Anti-Fgr Antibody, clone SuGr-7 14F3

Detect FGR using this mouse monoclonal Anti-Fgr Antibody, clone SuGr-7 14F3, Cat. No. MABS1140, validated for use in Western Blotting.

Anti-Fgr Antibody, clone SuGr-7 14F3 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: FGR, SRC2 UniProt Number: P09769
MABS1140
100 μg  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS1140
DescriptionAnti-Fgr Antibody, clone SuGr-7 14F3
Alternate Names
  • Tyrosine-protein kinase Fgr
  • Fgr
  • Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
  • Proto-oncogene c-Fgr
  • p55-Fgr
  • p58-Fgr
  • p58c-Fgr
Background InformationTyrosine-protein kinase Fgr (EC 2.7.10.2; UniProt P09769; also known as c-fgr, c-src2, c-src-2 proto-oncogene, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, p55-Fgr, p58-Fgr, p58c-Fgr, proto-oncogene c-Fgr) is encoded by the FGR (also known as SRC2) gene (Gene ID 2268) in human. Fgr is a member of the Src family of non-receptor protein tyrosine kinases (PTKs). Fgr contains N-terminal myristylation and palmitylation sites, a PTK catalytic domain, as well as SH2 and SH3 domains mediating interactions with phosphotyrosine-containing and proline-rich motifs, respectively. Fgr is a positive regulator of mast cell activation/degranulation and is essential for IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Fgr appears to act cooperatively with Fyn in the activation of Syk and its downstream targets in a manner that is counteracted by Lyn.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect FGR using this mouse monoclonal Anti-Fgr Antibody, clone SuGr-7 14F3, Cat. No. MABS1140, validated for use in Western Blotting.
Key Applications
  • Western Blotting
Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Fgr in 10 µg of Ramos cell lysate.
Biological Information
ImmunogenRecombinant protein corresponding to human Fgr.
CloneSuGr-7 14F3
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • FGR
  • SRC2
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~59 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Daudi cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Fgr in 10 µg of Daudi cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABS1140 04055977176995