Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABS1251 Anti-CYP11B2 Antibody, clone 41-17B

Anti-CYP11B2 Antibody, clone 41-17B is an antibody against CYP11B2 for use in Western Blotting, Immunohistochemistry, Immunofluorescence.

Anti-CYP11B2 Antibody, clone 41-17B MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: CYP11B2 UniProt Number: P19099
MABS1251
100 μg  
Purchase on Sigma-Aldrich

Speciální nabídky

Přehled

Replacement Information

Speciální nabídky

100% Performance Guaranteed

Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHC, IFMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS1251
DescriptionAnti-CYP11B2 Antibody, clone 41-17B
Alternate Names
  • Cytochrome P450 11B2, mitochondrial
  • CYP11B2
  • Aldosterone synthase
  • ALDOS
  • Aldosterone-synthesizing enzyme
  • CYPXIB2
  • Cytochrome P-450Aldo
  • Cytochrome P-450C18
  • Steroid 18-hydroxylase
Background InformationCytochrome P450 11B2, mitochondrial (EC1.14.15.4, EC1.14.15.5; UniProt P19099; also known as ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Cytochrome P450 subfamily XIB polypeptide 2, Steroid 11-beta-monooxygenase, Steroid 11-beta/18-hydroxylase, Mitochondrial cytochrome P450 family 11 subfamily B polypeptide 2) is encoded by the CYP11B2 (Also known as CPN2, CYP11B, CYP11BL, P450C18) gene in human (Gene ID 1585). CYP11B2 protein is a member of the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11B2 protein is localized to the mitochondrial inner membrane and exhibits steroid 18-hydroxylase activity and steroid 11 beta-hydroxylase activity. CYP11B2 gene mutations are known causes of corticosterone methyl oxidase 1 (CMO-1) deficiency, an autosomal recessive disorder of aldosterone biosynthesis.
References
Product Information
FormatPurified
HS Code3002 15 90
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-CYP11B2 Antibody, clone 41-17B is an antibody against CYP11B2 for use in Western Blotting, Immunohistochemistry, Immunofluorescence.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunofluorescence
Application NotesImmunohistochemistry Analysis: A representative lot detected CYP11B2 in normal adrenal glands (Gomez-Sanchez, C.E., et al. (2014). Mol. Cell Endocrinology. 383:111-117).
Immunofluorescence Analysis: A representative lot detected CYP11B2 in normal adrenal glands (Gomez-Sanchez, C.E., et al. (2014). Mol. Cell Endocrinology. 383:111-117).
Biological Information
ImmunogenChicken serum albumin-conjugated linear peptide corresponding to human CYP11B2 near the N-terminus.
EpitopeNear N-terminus
Clone41-17B
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Mouse based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CYP11B2
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~57 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in hCYP11B2-GFP-expressing HEK293 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected CYP11B2 in 10 µg of hCYP11B2-GFP-expressing HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABS1251 04055977169874

Documentation

Anti-CYP11B2 Antibody, clone 41-17B MSDS

Title

Safety Data Sheet (SDS) 

Anti-CYP11B2 Antibody, clone 41-17B Certificates of Analysis

TitleLot Number
Anti-CYP11B2, clone 41-17B - 2914880 2914880
Anti-CYP11B2, clone 41-17B - 3235651 3235651
Anti-CYP11B2, clone 41-17B - 3432498 3432498
Anti-CYP11B2, clone 41-17B - 3547780 3547780
Anti-CYP11B2, clone 41-17B - 3639188 3639188
Anti-CYP11B2, clone 41-17B - 3729954 3729954
Anti-CYP11B2, clone 41-17B - 3880370 3880370
Anti-CYP11B2, clone 41-17B - 3900434 3900434
Anti-CYP11B2, clone 41-17B - 3976054 3976054
Anti-CYP11B2, clone 41-17B - 4002465 4002465
Show more

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.