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MABF1487 Anti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody

This mouse monoclonal Anti- CD161 (NK1.1) Antibody (mouse), APC, clone PK136, Cat. No. MABF1487 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Klrb1b, Ly55b, Nkrp1b UniProt Number: P27812
MABF1487
25 μg  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
MFCMAPCMonoclonal Antibody
Description
Catalogue NumberMABF1487
DescriptionAnti- CD161 (NK1.1) (mouse), APC, clone PK136 Antibody
Alternate Names
  • Killer cell lectin-like receptor subfamily B member 1B allele A
  • CD161 antigen-like family member B
  • Lymphocyte antigen 55b (Ly-55b)
  • NKR-P1 34
  • Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B)
  • CD161b
  • CD161 (NK1.1)
Background InformationThe PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
References
Product Information
FormatAPC
PresentationPurified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Quality LevelMQ100
Applications
ApplicationThis mouse monoclonal Anti- CD161 (NK1.1) Antibody (mouse), APC, clone PK136, Cat. No. MABF1487 is validated for use in Flow Cytometry, for the detection of CD161 (NK1.1).
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenImmunogen information for this antibody is proprietary information.
ClonePK136
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Gene Symbol
  • Klrb1b
  • Ly55b
  • Nkrp1b
Purification MethodPurified by size-exclusion chromatography
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD161 (NK1.1) in one million C57Bl/6 splenocytes stained with FITC Anti-mouse CD3e.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABF1487 04055977292084

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Kategorie

Life Science Research > Antibodies and Assays > Primary Antibodies