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ABD12-25UG Anti-Aldehyde dehydrogenase 1 (ALDH1A1) (rabbit polyclonal)

This Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody is validated for use in WB for the detection of Aldehyde dehydrogenase 1 (ALDH1A1).

ABD12-25UG
25 μg  
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Description
Catalogue NumberABD12-25UG
DescriptionAnti-Aldehyde dehydrogenase 1 (ALDH1A1) (rabbit polyclonal)
Alternate Names
  • aldehyde dehydrogenase 1 family, member A1
  • ALDH class 1
  • Aldehyde dehydrogenase, cytosolic
  • retinaldehyde dehydrogenase 1
  • Aldehyde dehydrogenase family 1 member A1
  • retinal dehydrogenase 1
  • acetaldehyde dehydrogenase 1
  • aldehyde dehydrogenase 1, soluble
  • aldehyde dehydrogenase, liver cytosolic
Background InformationAldehyde dehydrogenase 1A1 (ALDH1A1) is also known as retinal dehydrogenase 1. It is thought to be a main converter of retinol to retinoic acid, which is very important in cell to cell signaling. ALDH1A1 may also be involved in inhibiting invasion in pancreatic cancer cells. More specifically, ALDH1A1 may regulate hematopoietic stem cell differentiation by disrupting the retinoid signaling.
References
Product Information
FormatAffinity Purified
Control
  • HepG2 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Aldehyde dehydrogenase 1 (ALDH1A1) Antibody is validated for use in WB for the detection of Aldehyde dehydrogenase 1 (ALDH1A1).
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human Aldehyde dehydrogenase 1.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteDemonstrated to react with human.
Other homologies: rat and mouse (91% sequence homology).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq].
Gene Symbol
  • RALDH1
  • ALDH11
  • ALHDII
  • ALDC
  • ALDH-E1
  • ALDH1
  • PUMB1
  • RalDH1
  • RALDH 1
  • ALDH1A1
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

CATALYTIC ACTIVITY: Retinal + NAD+ + H2O = retinoate + NADH.

PATHWAY: Cofactor metabolism; retinol metabolism.

SUBUNIT STRUCTURE: Homotetramer.

SUBCELLULAR LOCATION: Cytoplasm.

SEQUENCE SIMILARITIES: Belongs to the aldehyde dehydrogenase family.
Molecular Weight~54 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected Aldehyde dehydrogenase 1 on 10 µg of HepG2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
ABD12-25UG 04054839337376

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