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AB2209 Anti-ABBA Antibody

Anti-ABBA Antibody is an antibody against ABBA for use in WB, IC, IH.

Anti-ABBA Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: MGC79213 , ABBA UniProt Number: Q6P9S0
AB2209
100 µL  
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Speciální nabídky

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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, ICC, IHCRbSerumPolyclonal Antibody
Description
Catalogue NumberAB2209
DescriptionAnti-ABBA Antibody
Alternate Names
  • actin-bundling protein with BAIAP2 homology
Background InformationRadial glia play key roles in neuronal migration, axon guidance, and neurogenesis during development of the central nervous system. However, the molecular mechanisms regulating growth and morphology of these extended cells are unknown. ABBA, a novel member of the IRSp53/MIM protein family, is enriched in different types of radial glia. ABBA binds ATP-actin monomers with high affinity and deforms PIP2-rich membranes in vitro through its WH2 and IMdomains, respectively. In radial glia-like C6-R cells, ABBA localizes to the interface between the actin cytoskeleton and plasma membrane, and its depletion by RNAi leads to defects in lamellipodial dynamics and process extension. Together, ABBA acts as a novel regulator of actin and plasma membrane dynamics in radial glial cells, and provides evidence that the membrane binding/deformation activity is critical for the cellular functions of IRSp53/MIM/ABBA family proteins
References
Product Information
FormatSerum
Control
  • Mouse brain lysate
PresentationSerum with with 0.05% NaN3
Quality LevelMQ100
Applications
ApplicationAnti-ABBA Antibody is an antibody against ABBA for use in WB, IC, IH.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application NotesNon-Lot Specific Tested Application 1:
Immunocytochemistry: 1:50 dilution in mouse primary glial cell line and C6, C6-R rat cell line.

Non-Lot Specific Tested Application 2:
Immunohistochemistry: 1:1,000 in embryonic and adult brain tissue.

(See Reference for more information)
Biological Information
ImmunogenRecombinant protein.
HostRabbit
SpecificityCat. # AB2209 recognizes ABBA
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteHuman, Mouse and Rat. May react with Pan troglodytes and Macaca mulatta based on sequence homology. Reactivity with other species was not tested.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MGC79213
  • ABBA
UniProt Number
Molecular Weight~82 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely tested on mouse brain lysate
Lot Specific Tested Application 1: Western Blot
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
AB2209 04053252672910

Documentation

Anti-ABBA Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-ABBA Antibody Certificates of Analysis

TitleLot Number
Anti-ABBA - NG1539631 NG1539631

References

Reference overviewPub Med ID
ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension.
Saarikangas, Juha, et al.
J. Cell. Sci., 121: 1444-54 (2008)  2008

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