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172104 Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem

172104
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Katalogové čísloBalení ks/bal.
172104-50MG Skleněná láhev 50 mg
Description
OverviewTAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
Catalogue Number172104
Brand Family Calbiochem®
SynonymsTAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
References
ReferencesSackton, K.L., et al. 2014. Nature. In press.
Zeng, X., et al. 2010. Cancer Cell 18, 382.
Product Information
CAS number1784-03-8
FormWhite solid
Hill FormulaC₁₄H₂₂N₄O₄S · HCl
Chemical formulaC₁₄H₂₂N₄O₄S · HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
172104-50MG 04055977222906