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124033 Akt Inhibitor XVI, AT7867 - Calbiochem

124033
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Přehled

Tabulka spec. kláve

Empirical Formula
C₂₀H₂₀ClN₃

Products

Katalogové čísloBalení ks/bal.
124033-10MG Skleněná láhev 10 mg
Description
OverviewA cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47 nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20 nM), and p70S6K (IC50 = 85 nM) in an ATP-competitive manner (Ki = 18 nM using AKT2), with much reduced potency toward RSK1 (IC50 >100 nM) and a panel of 13 other cellular kinases (IC50 >1 µM). Shown to reduce cellular phosphorylation of GSK-3β (IC50 range from 2.08 to 4.45 µM), S6R, FKHRL1, and inhibit the proliferation of cancer cells exhibiting constitutive Akt pathway activation both in vitro (IC50 range from 0.94 to 11.86 µM) and in mice in vivo (20 mg/kg via i.p. or 90 mg/kg via p.o.).
Catalogue Number124033
Brand Family Calbiochem®
Synonymsp70S6K Inhibitor III, 4-(4-Chlorophenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine, PKA Inhibitor XIV, Chlorophenyl-pyrazolyl-phenyl-piperidine, S6K1 Inhibitor III
References
ReferencesGrimshaw, K.M., et al. 2010. Mol. Cancer Ther. 9, 1100.
Saxty, G., et al. 2007. J. Med. Chem. 50, 2293.
Product Information
FormWhite powder
Hill FormulaC₂₀H₂₀ClN₃
Chemical formulaC₂₀H₂₀ClN₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
124033-10MG 04055977205800