124029 Sigma-AldrichAkt Inhibitor XII, Isozyme-Selective, Akti-2 - Calbiochem
Akt Inhibitor XII, Isozyme-Selective, Akti-2, is a cell-permeable, selective inhibitor of Akt2 (IC50 = 805 nM). The inhibition is PH domain-dependent and non-competitive with ATP.
More>> Akt Inhibitor XII, Isozyme-Selective, Akti-2, is a cell-permeable, selective inhibitor of Akt2 (IC50 = 805 nM). The inhibition is PH domain-dependent and non-competitive with ATP. Less<<Synonyms: 1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and
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Tabulka spec. kláve
Empirical Formula |
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C₃₉H₃₉N₇O₂ • 3HCl |
Products
Katalogové číslo | Balení | ks/bal. | |
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124029-2MG | Skleněná láhev | 2 mg |
Description | |
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Overview | A cell-permeable Akti-1/2- (Cat. No. 124018) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP. |
Catalogue Number | 124029 |
Brand Family | Calbiochem® |
Synonyms | 1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and |
References | |
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References | Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49. |
Product Information | |
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Form | Yellow solid |
Hill Formula | C₃₉H₃₉N₇O₂ • 3HCl |
Chemical formula | C₃₉H₃₉N₇O₂ • 3HCl |
Hygroscopic | Hygroscopic |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥97% by HPLC (mixture of regioisomers) |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Katalogové číslo | GTIN |
124029-2MG | 04055977205763 |