Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

124029 Akt Inhibitor XII, Isozyme-Selective, Akti-2 - Calbiochem

124029
Purchase on Sigma-Aldrich

Přehled

Tabulka spec. kláve

Empirical Formula
C₃₉H₃₉N₇O₂ • 3HCl

Products

Katalogové čísloBalení ks/bal.
124029-2MG Skleněná láhev 2 mg
Description
OverviewA cell-permeable Akti-1/2- (Cat. No. 124018) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP.
Catalogue Number124029
Brand Family Calbiochem®
Synonyms1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and
References
ReferencesZhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49.
Product Information
FormYellow solid
Hill FormulaC₃₉H₃₉N₇O₂ • 3HCl
Chemical formulaC₃₉H₃₉N₇O₂ • 3HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAkt Inhibitor XII, Isozyme-Selective, Akti-2, is a cell-permeable, selective inhibitor of Akt2 (IC50 = 805 nM). The inhibition is PH domain-dependent and non-competitive with ATP.
Biological Information
Purity≥97% by HPLC (mixture of regioisomers)
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
124029-2MG 04055977205763