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124013 Akt Inhibitor VI, Akt-in - Calbiochem

124013
  
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Tabulka spec. kláve

Empirical Formula
C₈₈H₁₂₃N₂₃O₂₃
Description
OverviewA reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
Catalogue Number124013
Brand Family Calbiochem®
SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
References
ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as an acetate salt.
Hill FormulaC₈₈H₁₂₃N₂₃O₂₃
Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetAkt
Primary Target IC<sub>50</sub>Kd ~18 µM in binding to Akt-PH domain
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
124013 0