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28745 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dibutyryl-cAMP, Na

Primary Target: PKA
28745
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Tabulka spec. kláve

CAS #Empirical Formula
16980-89-5C₁₈H₂₃N₅O₈P · Na

Products

Katalogové čísloBalení ks/bal.
28745-100MG Plastová ampulka 100 mg
Přidat k oblíbeným položkám
28745-25MG Plastová ampulka 25 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
Catalogue Number28745
Brand Family Calbiochem®
SynonymsDibutyryl-cAMP, Na
References
ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
Product Information
CAS number16980-89-5
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₁₈H₂₃N₅O₈P · Na
Chemical formulaC₁₈H₂₃N₅O₈P · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Biological Information
Primary TargetPKA
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information according to GHS
RTECSES5055500
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
Global Trade Item Number
Katalogové číslo GTIN
28745-100MG 04055977197839
28745-25MG 04055977090970