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171256 AMPK Activator - CAS 849727-81-7 - Calbiochem

The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I

Primary Target: AMPK
171256
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Tabulka spec. kláve

CAS #Empirical Formula
849727-81-7C₂₂H₂₁FO₄

Products

Katalogové čísloBalení ks/bal.
171256-5MG Skleněná láhev 5 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
Catalogue Number171256
Brand Family Calbiochem®
Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
References
ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.
Product Information
CAS number849727-81-7
ATP CompetitiveN
FormLight yellow solid
Hill FormulaC₂₂H₂₁FO₄
Chemical formulaC₂₂H₂₁FO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetAMPK
Primary Target IC<sub>50</sub>EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
171256-5MG 04055977207118