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401003 (±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM).

(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [(±)-2-(4-Isobutylphenyl)-propionic Acid

Primary Target: COX-1
401003
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Tabulka spec. kláve

CAS #Empirical Formula
15687-27-1C₁₃H₁₈O₂

Products

Katalogové čísloBalení ks/bal.
401003-1GM Plastová ampulka 1 gm
Přidat k oblíbeným položkám
Description
OverviewA nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 µM). Inhibits COX-2 at higher concentrations (IC50 = 223 µM). Blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β40 and 42) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM).
Catalogue Number401003
Brand Family Calbiochem®
Synonyms[(±)-2-(4-Isobutylphenyl)-propionic Acid
References
ReferencesAsanuma, M., et al. 2001. J. Neurochem. 76, 1895.
Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.
Product Information
CAS number15687-27-1
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₃H₁₈O₂
Chemical formulaC₁₃H₁₈O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>4.85 µM against COX-1
Purity≥98% by titration
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSMU6640000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Katalogové číslo GTIN
401003-1GM 04055977189377