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559395 SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem

SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

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Sinónimos: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride

Primary Target: p38 MAP kinase
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559395
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Tabla espec. clave

CAS #Empirical Formula
869185-85-3C₂₁H₁₆FN₃OS · HCl

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      Description
      OverviewA water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
      Catalogue Number559395
      Brand Family Calbiochem®
      Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor XVI, Hydrochloride
      Product Information
      CAS number869185-85-3
      ATP CompetitiveN
      FormBright yellow solid
      Hill FormulaC₂₁H₁₆FN₃OS · HCl
      Chemical formulaC₂₁H₁₆FN₃OS · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetp38 MAP kinase
      Primary Target IC<sub>50</sub>34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Número de referencia GTIN
      559395-1MG 04055977192568