Millipore Sigma Vibrant Logo

524400 Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: PMA, TPA, PKC Activator I

Primary Target: Protein Kinase C
View Products on Sigmaaldrich.com
524400
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
16561-29-8C₃₆H₅₆O₈

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
524400-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Frasco de vidrio 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      524400-25MG
      Comprobando disponibilidad...
      —
      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Frasco de vidrio 25 mg
          Recuperando precio...
          No pudo obtenerse el precio
          La cantidad mínima tiene que ser múltiplo de
          Maximum Quantity is
          Al finalizar el pedido Más información
          Ahorró ()
           
          —
          Solicitar precio
          		 —
          524400-5MG
          Comprobando disponibilidad...
          —
          Disponibilidad a confirmar Disponibilidad a confirmar
          Ingrese cantidad 
          Suspendido
          Cantidades limitadas disponibles
          Debe confirmarse disponibilidad
            El resto: se avisará
              El resto: se avisará
              Se avisará
              Póngase en contacto con el Servicio de Atención al Cliente
              Contact Customer Service

              		 Frasco de vidrio 5 mg
              Recuperando precio...
              No pudo obtenerse el precio
              La cantidad mínima tiene que ser múltiplo de
              Maximum Quantity is
              Al finalizar el pedido Más información
              Ahorró ()
               
              —
              Solicitar precio
              		 —
              Description
              OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
              Catalogue Number524400
              Brand Family Calbiochem®
              SynonymsPMA, TPA, PKC Activator I
              References
              ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
              Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
              Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
              Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
              Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
              Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
              Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
              Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
              Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
              Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
              Perchellet, J. 1985. Carcinogenesis 6, 567.
              Nishizuka, Y. 1984. Science 255, 1365.
              Mastro, A. 1982. Lymphokines 6, 263.
              Product Information
              CAS number16561-29-8
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₃₆H₅₆O₈
              Chemical formulaC₃₆H₅₆O₈
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              ApplicationPhorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
              Biological Information
              Primary TargetProtein Kinase C
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSQH4377000
              Safety Information
              R PhraseR: 21-38

              Harmful in contact with skin.
              Irritating to skin.
              S PhraseS: 26-27-36-45

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Take off immediately all contaminated clothing.
              Wear suitable protective clothing.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Número de referencia GTIN
              524400-1MG 04055977270945
              524400-25MG 04055977270969
              524400-5MG 04055977270976

              Documentation

              Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Ficha datos de seguridad (MSDS)

              Título

              Ficha técnica de seguridad del material (MSDS) 

              Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Certificados de análisis

              CargoNúmero de lote
              524400

              Referencias bibliográficas

              Visión general referencias
              Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
              Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
              Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
              Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
              Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
              Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
              Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
              Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
              Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
              Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
              Perchellet, J. 1985. Carcinogenesis 6, 567.
              Nishizuka, Y. 1984. Science 255, 1365.
              Mastro, A. 1982. Lymphokines 6, 263.

              Folleto

              Cargo
              Caspases and other Apoptosis Related Tools Brochure

              Citas

              Título
            • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
            • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
            • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
            • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
              		•
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision19-October-2010 JSW
              SynonymsPMA, TPA, PKC Activator I
              DescriptionExtremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
              FormWhite solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number16561-29-8
              RTECSQH4377000
              Chemical formulaC₃₆H₅₆O₈
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
              Toxicity Harmful
              ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
              Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
              Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
              Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
              Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
              Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
              Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
              Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
              Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
              Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
              Perchellet, J. 1985. Carcinogenesis 6, 567.
              Nishizuka, Y. 1984. Science 255, 1365.
              Mastro, A. 1982. Lymphokines 6, 263.
              Citation
            • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
            • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
            • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
            • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
              		•