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516481 Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
26305-03-3C₃₄H₆₃N₅O₉

Precios y disponibilidad

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516481-5MG
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      Description
      OverviewA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
      Effective concentration: 1.0 µM.
      Catalogue Number516481
      Brand Family Calbiochem®
      SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
      References
      ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
      Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
      Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
      Carraway, R.E., et al. 1991. Peptides 12, 107.
      Eid, M., et al. 1981. Biochem. J. 197, 465.
      Umezawa, H., et al. 1970. J. Antibiot. 23, 259.
      Product Information
      CAS number26305-03-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₄H₆₃N₅O₉
      Chemical formulaC₃₄H₆₃N₅O₉
      Optical rotationOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin D
      Primary Target IC<sub>50</sub>EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSC6155000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      516481-5MG 04055977198836

      Documentation

      Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      516481

      Referencias bibliográficas

      Visión general referencias
      Isahara, K., et al. 1999. Neuroscience 91, 233.
      Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
      Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
      Carraway, R.E., et al. 1991. Peptides 12, 107.
      Eid, M., et al. 1981. Biochem. J. 197, 465.
      Umezawa, H., et al. 1970. J. Antibiot. 23, 259.

      Folleto

      Cargo
      Western Blotting Tools

      Licencias necesarias e Información técnica

      Cargo
      Protein Blotting Handbook: 6th Edition
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2013 JSW
      SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
      DescriptionA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
      FormWhite solid
      Recommended reaction conditions
      Activity:
      Activity is measured by inhibition of pepsin. 1 U corresponds to the amount of inhibitor that reduces the activity of pepsin by 1 U (1 U of enzyme corresponds to the amount of enzyme that results in the increases the absorbance at 280 nm by 0.001 per min at pH 2.0, 37°C.)
      CAS number26305-03-3
      RTECSSC6155000
      Chemical formulaC₃₄H₆₃N₅O₉
      Purity≥98% by HPLC
      SolubilityDMSO (1 mg/ml) or Methanol (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 7147
      ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
      Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
      Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
      Carraway, R.E., et al. 1991. Peptides 12, 107.
      Eid, M., et al. 1981. Biochem. J. 197, 465.
      Umezawa, H., et al. 1970. J. Antibiot. 23, 259.