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420119 JNK Inhibitor II - CAS 129-56-6 - Calbiochem

JNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).

JNK Inhibitor II - CAS 129-56-6 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II

Primary Target: JNK 1, JNK 2, JNK 3
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420119
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
129-56-6C₁₄H₈N₂O

Precios y disponibilidad

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420119-25MG
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      420119-5MG
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      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 5 mg
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          No pudo obtenerse el precio
          La cantidad mínima tiene que ser múltiplo de
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          Ahorró ()
           
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          Description
          OverviewA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
          Catalogue Number420119
          Brand Family Calbiochem®
          SynonymsAnthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
          References
          ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
          Product Information
          CAS number129-56-6
          ATP CompetitiveY
          FormYellowish orange solid
          Hill FormulaC₁₄H₈N₂O
          Chemical formulaC₁₄H₈N₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          ApplicationJNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).
          Biological Information
          Primary TargetJNK 1, JNK 2, JNK 3
          Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCB4585000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          420119-25MG 04055977187977
          420119-5MG 07790788050092

          Documentation

          JNK Inhibitor II - CAS 129-56-6 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          JNK Inhibitor II - CAS 129-56-6 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          420119

          Referencias bibliográficas

          Visión general referencias
          Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.

          Póster

          Cargo
          Human Kinome & InhibitorSelect™ Libraries

          Citas

          Título
        • Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.
        • Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling. (2005) Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. Journal of Pharmacology and Experimental Therapeutics in press,.
        • Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-June-2009 RFH
          SynonymsAnthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
          DescriptionA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
          FormYellowish orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number129-56-6
          RTECSCB4585000
          Chemical formulaC₁₄H₈N₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (15 mg/ml). For every 10 µM concentration of JNK Inhibitor II, include 0.1% DMSO in the culture medium. Pre-warming of culture medium and addition of BSA to the medium may enhance its solubility.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
          Citation
        • Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.
        • Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling. (2005) Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. Journal of Pharmacology and Experimental Therapeutics in press,.
        • Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.
          		•