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361556 GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem

The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Deph

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Sinónimos: 1-Methyl-BIO

Primary Target: Relevant kinase inactive control
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361556
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Tabla espec. clave

CAS #Empirical Formula
710323-61-8C₁₇H₁₂BrN₃O₂

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361556-1MG
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      Description
      OverviewA cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
      Catalogue Number361556
      Brand Family Calbiochem®
      Synonyms1-Methyl-BIO
      References
      ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number710323-61-8
      ATP CompetitiveN
      FormDark red solid
      Hill FormulaC₁₇H₁₂BrN₃O₂
      Chemical formulaC₁₇H₁₂BrN₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetRelevant kinase inactive control
      Primary Target IC<sub>50</sub>> 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      361556-1MG 04055977214161