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574215 D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

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Sinónimos: 1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane

Primary Target: Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
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574215
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Descripción

Tabla espec. clave

CAS #Empirical Formula
4478-93-7C₆H₁₁NOS₂

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      Description
      OverviewAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
      Catalogue Number574215
      Brand Family Calbiochem®
      Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
      References
      ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
      Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
      Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
      Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
      Maheo, K., et al. 1997. Cancer Res. 57, 3649.
      Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
      Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
      Product Information
      CAS number4478-93-7
      ATP CompetitiveN
      FormSlight yellow liquid
      Hill FormulaC₆H₁₁NOS₂
      Chemical formulaC₆H₁₁NOS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationD,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
      Biological Information
      Primary TargetPotent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
      Purity≥98% by UPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      574215-25MG 04055977189568