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235420 Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: CPP32/Apopain Inhibitor, Ac-DEVD-CHO

Primary Target: Capase-3, capase-6, capase-7, capase-8, capase-10
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235420
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
169332-60-9C₂₀H₃₀N₄O₁₁

Precios y disponibilidad

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235420-1MG
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      Description
      OverviewA very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
      Catalogue Number235420
      Brand Family Calbiochem®
      SynonymsCPP32/Apopain Inhibitor, Ac-DEVD-CHO
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Nicholson, D.W. 1996. Nature Biotech. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Product Information
      CAS number169332-60-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₃₀N₄O₁₁
      Chemical formulaC₂₀H₃₀N₄O₁₁
      ReversibleY
      Sold on the basis of peptide contentY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCapase-3, capase-6, capase-7, capase-8, capase-10
      Primary Target IC<sub>50</sub>200 pM against caspase-3
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceAc-Asp-Glu-Val-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      235420-1MG 07790788060220

      Documentation

      Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Caspase-3 Inhibitor I - CAS 169332-60-9 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      235420

      Referencias bibliográficas

      Visión general referencias
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Nicholson, D.W. 1996. Nature Biotech. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Nicholson, D.W., et al. 1995. Nature 376, 37.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure

      Citas

      Título
    • Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.
    • So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
    • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsCPP32/Apopain Inhibitor, Ac-DEVD-CHO
      DescriptionA specific and reversible inhibitor of CPP32/Apopain/Yama (IC50 = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.
      FormWhite solid
      CAS number169332-60-9
      Chemical formulaC₂₀H₃₀N₄O₁₁
      Peptide SequenceAc-Asp-Glu-Val-Asp-CHO
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Nicholson, D.W. 1996. Nature Biotech. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Citation
    • Qian Zhang and Bibhash C. Paria. (2006) Importance of Uterine Cell Death, Renewal and Their Hormonal Regulation in Hamsters That Show Progesterone-dependent Implantation. Endocrinology 147, 2215-2227.
    • So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
    • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
      		•