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616370 Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem

Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activities.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Pancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor

Primary Target: chymotrypsin
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616370
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CAS #
9087-70-1

Precios y disponibilidad

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      Description
      OverviewA competitive and reversible inhibitor of esterases and proteases. Forms a tight complex with and blocks the active site of the enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the prephase of blood clotting, kallikrein (Kd = 1 x 10-7 M), plasmin (Kd = 2.3 x 10-10 M) , tissue and leukocytic proteinases, and trypsin (Kd = 5 x 10-14 M). Does not inhibit Factor Xa and thrombin. It is relatively acid- and heat-stable. Useful as a serine protease inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
      Effectively inhibits target proteases at equimolar concentration.
      Note: 1 KIU = 0.025 antiplasmin units (APU) = 0.0016 trypsin inhibitor units (using porcine trypsin) = 0.0009756 trypsin inhibitor units (using bovine trypsin).
      Catalogue Number616370
      Brand Family Calbiochem®
      SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
      References
      ReferencesZhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
      Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
      Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
      Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
      Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
      McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
      Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
      Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
      Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
      Product Information
      CAS number9087-70-1
      Activity≥5500 KIU/mg dry weight
      Unit of DefinitionOne Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
      ATP CompetitiveN
      FormWhite to off-white crystalline solid
      Hygroscopic Hygroscopic
      PI10.5
      ReversibleY
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetchymotrypsin
      Primary Target IC<sub>50</sub>Kd = 1 x 10-7 M, 2.3 x 10-10 M, 5 x 10-14 M, against kallikrein, plasmin, and trypsin, respectively
      Purity≥95% by gel filtration
      Physicochemical Information
      Cell permeableN
      Contaminantsendotoxin: ≤10 EU/mg
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYN5080000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      616370-10MG 07790788056292

      Documentation

      Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      616370

      Referencias bibliográficas

      Visión general referencias
      Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
      Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
      Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
      Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
      Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
      McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
      Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
      Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
      Kassell, B., et al. 1970. Methods Enzymol. 19, 845.

      Folleto

      Cargo
      Bulk Product Guide

      Citas

      Título
    • Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-February-2012 RFH
      SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor
      DescriptionA competitive and reversible inhibitor of esterase and protease activity. Forms a tight complex with and blocks the active site of target enzymes. Inhibits a number of different proteases, including chymotrypsin, coagulation factors involved in the pre-phase of blood clotting, kallikrein (Kd = 1 X 10-7 M), plasmin (Kd = 2.3 X 10-10 M), tissue and leukocyte proteinases, and trypsin (Kd = 5 X 10-14 M). Does not inhibit Factor Xa or thrombin. Reported to be relatively acid and heat stable. Effectively inhibits target proteases at equimolar concentration. Useful as a serine proteinase inhibitor during purification of proteins and in studies of zymogen activation systems. Reported to suppress virus HA cleavage and limit reproduction of human and avian influenza viruses with a single arginine in the HA cleavage site.
      FormWhite to off-white crystalline solid
      CAS number9087-70-1
      RTECSYN5080000
      Purity≥95% by gel filtration
      Contaminantsendotoxin: ≤10 EU/mg
      Activity≥5500 KIU/mg dry weight
      Unit definitionOne Kallikrein Inhibitory Unit (K.I.U.) is defined as the quantity of protease inhibitor that will inhibit two kallikrein units by 50% under optimal conditions. Note: 1 KIU = 0.025 antiplasmin units (APU) or 0.0031 trypsin inhibitor units.
      SolubilityH₂O (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Standard Handling
      Merck USA index14, 757
      ReferencesZhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
      Roberts, R.F., et al. 1998. Ann. Thorac. Surg. 66, 225.
      Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
      Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
      Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
      McKeehan, W.L., et al. 1986. J. Biol. Chem. 261, 5378.
      Fritz, H., and Wunderer, G. 1983. Arzneim. Forsch. 33, 479.
      Rijken, D.C., and Collen, D. 1981. J. Biol. Chem. 256, 7035.
      Kassell, B., et al. 1970. Methods Enzymol. 19, 845.
      Citation
    • Zhirnov, O.P., et al. 2011. Antiviral Res. 92, 27.
      		•