On-Demand Webinar

Enhancing Bioavailability with Inorganic Drug Carriers

Duration: 1 Hour
Speakers: Gudrun Birk, Head of Controlled Release, Merck and Dr. Alena Wieber, Head of Customized and Oral Formulations, Merck

Abstract: Most active pharmaceutical ingredients (API) lack aqueous solubility during pharmaceutical drug product development, and one in three drug candidates offers poor bioavailability (BA) in the preclinical stage. Various strategies are commonly used to enhance drug bioavailability, and carriers can improve the aqueous solubility of drug candidates. Inorganic carriers such as porous silica-based particles are advantageous, as the material is safe (GRAS) and can easily be formulated into a final oral dosage form (tablet or capsule). This webinar discusses the proof of concept and formulation strategy for silica-based drug carriers, exemplified by different case studies of poorly soluble drug candidates.

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