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654380 Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

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654380
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
11089-65-9C₃₉H₆₄N₄O₁₆

Pricing & Availability

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654380-10MG
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      654380-50MG
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          		 Alu drum 50 mg
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          Description
          OverviewA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
          Catalogue Number654380
          Brand Family Calbiochem®
          References
          ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
          Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
          Product Information
          CAS number11089-65-9
          FormWhite to off-white solid
          Hill FormulaC₃₉H₆₄N₄O₁₆
          Chemical formulaC₃₉H₆₄N₄O₁₆
          ReconstitutionAqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          Biological Information
          Primary TargetN-linked glycosylation
          Secondary targetthrombin-induced Ca2+ mobilization in cells
          Purity≥98% by HPLC (A+B+C+D)
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYO7980200
          Safety Information
          R PhraseR: 26/27/28-60-61

          Very toxic by inhalation, in contact with skin and if swallowed.
          May impair fertility.
          May cause harm to the unborn child.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          654380-10MG 04055977184686
          654380-50MG 04055977184693

          Documentation

          Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          654380

          References

          Reference overview
          Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
          Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.

          Citations

          Title
        • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
        • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-September-2007 RFH
          DescriptionA nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells.
          FormWhite to off-white solid
          CAS number11089-65-9
          RTECSYO7980200
          Chemical formulaC₃₉H₆₄N₄O₁₆
          Structure formulaStructure formula
          Purity≥98% by HPLC (A+B+C+D)
          SolubilityDMSO (10 mg/ml), DMF, or Pyridine. Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 9819
          ReferencesTordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
          Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
          Citation
        • Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.
        • Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.
        • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
          		•