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625625 Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside

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625625
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
6138-23-4C₁₂H₂₂O₁₁ · 2H₂O

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      625625-50GM
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          Description
          OverviewNon-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.
          Catalogue Number625625
          Brand Family Calbiochem®
          Synonyms1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
          References
          ReferencesSarkar, S., et al. 2007. J. Biol. Chem. In press.
          Tanaka, M., et al. 2004. Nat. Med. 10, 148.
          Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.
          Product Information
          CAS number6138-23-4
          FormSolid
          Hill FormulaC₁₂H₂₂O₁₁ · 2H₂O
          Chemical formulaC₁₂H₂₂O₁₁ · 2H₂O
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥97.5% by Assay
          Physicochemical Information
          ContaminantsHeavy metals: <10 ppm; iron: <5 ppm
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 24/25-37-45

          Avoid contact with skin and eyes.
          Wear suitable gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          625625-1KG 04055977262728
          625625-50GM 07790788051976

          Documentation

          Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          625625

          References

          Reference overview
          Sarkar, S., et al. 2007. J. Biol. Chem. In press.
          Tanaka, M., et al. 2004. Nat. Med. 10, 148.
          Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-April-2010 JSW
          Synonyms1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
          DescriptionNon-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.
          FormSolid
          CAS number6138-23-4
          Chemical formulaC₁₂H₂₂O₁₁ · 2H₂O
          Structure formulaStructure formula
          Purity≥97.5% by Assay
          ContaminantsHeavy metals: <10 ppm; iron: <5 ppm
          SolubilityH₂O (100 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Toxicity Standard Handling
          Merck USA index14, 9580
          ReferencesSarkar, S., et al. 2007. J. Biol. Chem. In press.
          Tanaka, M., et al. 2004. Nat. Med. 10, 148.
          Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.