Prostak™ Microfiltration Modules
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Overview
Specifications
Ordering Information
Documentation
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Categories
| Biopharmaceutical Manufacturing > Upstream Processing > Cell Culture > Cell Culture Clarification > Millistak+ Pod > Prostak |
Description
Prostak™ microfiltration modules are tangential flow filtration devices in a stacked plate configuration with open feed channels. A microporous membrane, Durapore® polyvinylidene fluoride (PVDF), is bonded on both sides of each plate. The plates are then stacked in parallel forming stacks. Prostak™ microfiltration open-channel modules are available in four sizes: 2, 4, 10 and 20 stacks, making them applicable for bench-top, pilot, and production scale systems.
The modules can be integrity tested and steam sterilized for 20 cycles.
Prostak™ MF modules must be used with a support holder, which controls deflection and provides sanitary fittings for connection to external piping. Sanitary gaskets supplied with the module provide a leak-free connection between the module(s) and the holder.
Typical Applications
Prostak™ microfiltration is used for separations where viscosity and suspended solids levels of the feed stream require an open feed channel. They are typically used in perfusion applications or in the clarification/harvest of:
- Mammalian, bacterial and mycelial cell suspensions
- Emulsions and colloidal suspension
- Viruses, proteins and other bio-organic macromolecular solutions
- Polysaccharides and other high viscosity solutions
- Yeast, algae, and other high solids suspensions
- Protein precipitate
- Vaccines
| Physical Specifications | ||||
| 2 Stacks | 4 Stacks | 10 Stacks | 20 Stacks | |
| Dry Weight | 1.6 kg (3.5 lbs) | 2.1 kg (4.6 lbs) | 3.6 kg (7.9 lbs) | 6.2 kg (13.7 lbs) |
| Length | 38.9 cm (15.3 in.) | 38.9 cm (15.3 in.) | 38.9 cm (15.3 in.) | 38.9 cm (15.3 in.) |
| Width | 19.8 cm (7.8 in.) | 19.8 cm (7.8 in.) | 19.8 cm (7.8 in.) | 19.8 cm (7.8 in.) |
| Height | 4.6 cm (1.8 in.) | 5.6 cm (2.2 in.) | 8.1 cm (3.2 in.) | 12.4 cm (4.9 in.) |
| Total Internal Volume | 500 ml | 700 ml | 1250 ml | 2500 ml |
| Feed Internal Volume | 300 ml | 420 ml | 750 ml | 1500 ml |
| Filtrate Internal Volume | 200 ml | 280 ml | 500 ml | 1000 ml |
| Membrane Area | 0.17 m2 | 0.33 m2 | 0.84 m2 | 1.7 m2 |
| Materials of Construction | ||||
| Membrane | Hydrophilic or Hydrophobic Durapore® (PVDF) | |||
| Plates and End Caps | Polysulfone, 10% glass filled | |||
| Sanitary Gaskets | Silicone | |||
| Operating Guidelines | ||||
| Prefiltration Required | 150 µm | |||
| Maximum Inlet Pressure | ||||
| at < 50°C | 5.6 bar (80 psi)* | |||
| at 50 - 80°C | 4.2 bar (60 psi) | |||
| Maximum Transmembrane Pressure - Forward | ||||
| at < 50°C | 4.2 bar (60 psi)* | |||
| at 50 - 80°C | 2.1 bar (30 psi) | |||
| pH Range | ||||
| short duration (1 hr cycle) | 1 - 11 (hydrophilic Durapore®) 1 - 13 (hydrophobic Durapore®) |
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| continuous | 2 – 10 (hydrophilic Durapore®) 2 – 12 (hydrophobic Durapore®) |
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| Steaming (In Place) | ||||
| Steam Pressure | 20 psi | |||
| Cycle Time | 1 hour | |||
| *Durapore® 0.65 µm membrane is 3.5 bar (50 psi) maximum forward pressure | ||||