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420600 Ketoconazole - CAS 65277-42-1 - Calbiochem

An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities.

Ketoconazole - CAS 65277-42-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I

Primary Target: 5-LO
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420600
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
65277-42-1C₂₆H₂₈Cl₂N₄O₄

Pricing & Availability

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420600-50MG
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      Description
      OverviewAn inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
      Catalogue Number420600
      Brand Family Calbiochem®
      Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
      References
      Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.
      Product Information
      CAS number65277-42-1
      FormOff-white solid
      Hill FormulaC₂₆H₂₈Cl₂N₄O₄
      Chemical formulaC₂₆H₂₈Cl₂N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-LO
      Primary Target IC<sub>50</sub>26 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTK7912300
      Safety Information
      R PhraseR: 25-40-63-36/37/38

      Toxic if swallowed.
      Limited evidence of a carcinogenic effect.
      Possible risk of harm to the unborn child.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      420600-50MG 04055977187618

      Documentation

      Ketoconazole - CAS 65277-42-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ketoconazole - CAS 65277-42-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      420600

      References

      Reference overview
      van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
      DescriptionAn inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
      FormOff-white solid
      CAS number65277-42-1
      RTECSTK7912300
      Chemical formulaC₂₆H₂₈Cl₂N₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 5302
      Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.