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298711 Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Diethyl Oxydiformate, DEPC

Primary Target: Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
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298711
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1609-47-8C₆H₁₀O₅

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298711-25GM
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      		 Plastic ampoule 25 gm
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      Description
      OverviewInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
      Catalogue Number298711
      Brand Family Calbiochem®
      SynonymsDiethyl Oxydiformate, DEPC
      References
      ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
      Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
      Product Information
      CAS number1609-47-8
      ATP CompetitiveN
      FormClear colorless liquid
      Hill FormulaC₆H₁₀O₅
      Chemical formulaC₆H₁₀O₅
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
      Purity≥96% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLQ9350000
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      298711-25GM 07790788049041

      Documentation

      Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Diethyl Pyrocarbonate - CAS 1609-47-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      298711

      References

      Reference overview
      Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
      Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2019 JSW
      SynonymsDiethyl Oxydiformate, DEPC
      DescriptionInhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
      FormClear colorless liquid
      CAS number1609-47-8
      RTECSLQ9350000
      Chemical formulaC₆H₁₀O₅
      Purity≥96% by titration
      SolubilityChloroform or Ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Harmful
      Merck USA index14, 7998
      ReferencesShoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
      Blumbers, D.O. 1987. Methods Enzymol. 152, 20.