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219007 Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem

Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-VAD-FMK

Primary Target: general caspase inhibitor
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219007
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
161401-82-7C₂₁H₂₈FN₃O₇

Pricing & Availability

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219007-1MG
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      Description
      OverviewAn irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.
      Catalogue Number219007
      Brand Family Calbiochem®
      SynonymsZ-VAD-FMK
      References
      ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
      Product Information
      CAS number161401-82-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₂₈FN₃O₇
      Chemical formulaC₂₁H₂₈FN₃O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetgeneral caspase inhibitor
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Val-Ala-Asp-CH₂F*
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219007-1MG 07790788048648

      Documentation

      Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      219007

      References

      Reference overview
      Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
    • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
    • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
    • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
    • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      SynonymsZ-VAD-FMK
      DescriptionA cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.
      FormOff-white solid
      CAS number161401-82-7
      Chemical formulaC₂₁H₂₈FN₃O₇
      Peptide SequenceZ-Val-Ala-Asp-CH₂F*
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (9 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
      Citation
    • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
    • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
    • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
    • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
    • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
      		•